VNDA

Tradipitant

Pruritus in Atopic Dermatitis | EPIONE

Phase 3

Exp Date

TBD

Amp Volatility Score

Catalyst Info & Data Links

TITLE: Tradipitant for COVID-19 - Phase 3 Safety & Efficacy Data

  • ClinicalTrial.gov (NCT03568331): Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE)

  • ClinicalTrial.gov (NCT04140695): Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2) (EPIONE2)


WHAT IS THE NEXT CATALYST EVENT?

  • TBD


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • TBD


PRIOR DATA

PRESS RELEASES

MECHANSIM OF ACTION / RATIONALE

  • Tradipitant is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor; NK1R; NK-1R) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. Upon oral administration, tradipitant competitively binds to and blocks the activity of the NK1R in the central nervous system (CNS), thereby inhibiting the binding of the endogenous ligand and neuropeptide, substance P (SP; neurokinin-1; NK1). This inhibits SP/NK1-mediated signal transduction and may prevent both SP-induced emesis and pruritis. In addition, inhibition of SP/NK1R signaling also reduces neurogenic inflammation which is triggered by the release of neuropeptides, such as substance P, from nerve cells. NK1R is a G protein-coupled receptor (GPCR) that preferentially binds to SP, a neuropeptide secreted by neuronal cells and inflammatory cells. (source - National Library of Medicine (National Institute of Health))

Updated by HC

#VNDA, #Tradipitant, #Pruritus, #Atopic_Dermatitis, #EPIONE

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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