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Catalyst Info & Data Links
TITLE: Tradipitant for Motion Sickness
ClinicalTrial.gov (NCT03772340): (Phase 2 - Completed) Motion Sifnos: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness
ClinicalTrial.gov (NCT04327661): Motion Syros: A Randomized Study Investigating the Efficacy of Tradipitant in Treating Motion Sickness
WHAT IS THE NEXT CATALYST EVENT?
WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?
MECHANSIM OF ACTION / RATIONALE
Tradipitant is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor; NK1R; NK-1R) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. Upon oral administration, tradipitant competitively binds to and blocks the activity of the NK1R in the central nervous system (CNS), thereby inhibiting the binding of the endogenous ligand and neuropeptide, substance P (SP; neurokinin-1; NK1). This inhibits SP/NK1-mediated signal transduction and may prevent both SP-induced emesis and pruritis. In addition, inhibition of SP/NK1R signaling also reduces neurogenic inflammation which is triggered by the release of neuropeptides, such as substance P, from nerve cells. NK1R is a G protein-coupled receptor (GPCR) that preferentially binds to SP, a neuropeptide secreted by neuronal cells and inflammatory cells. (source - National Library of Medicine (National Institute of Health))
Updated by HC
#VNDA, #Tradipitant, #Motion_Sickness
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