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Catalyst Info & Data Links
TITLE: Tradipitant for Gastroparesis- NDA Filing
ClinicalTrial.gov (NCT04028492) Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis
WHAT IS THE CATALYST EVENT?
WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?
2019: Tradipitant complete responder analysis in gastroparesis patients: 1238. American Journal of Gastroenterology, 114(2019 ACG Annual Meeting Abstracts), S691.
~5 million people in the United States have gastroparesis, many remain undiagnosed (learn more)
MECHANISM OF ACTION / RATIONALE
Tradipitant is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor; NK1R; NK-1R) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. Upon oral administration, tradipitant competitively binds to and blocks the activity of the NK1R in the central nervous system (CNS), thereby inhibiting the binding of the endogenous ligand and neuropeptide, substance P (SP; neurokinin-1; NK1). This inhibits SP/NK1-mediated signal transduction and may prevent both SP-induced emesis and pruritis. In addition, inhibition of SP/NK1R signaling also reduces neurogenic inflammation which is triggered by the release of neuropeptides, such as substance P, from nerve cells. NK1R is a G protein-coupled receptor (GPCR) that preferentially binds to SP, a neuropeptide secreted by neuronal cells and inflammatory cells (Learn more - National Library of Medicine)
Updated by HC
#VNDA, #Tradipitant, #Gastroparesis, #neurokinin, #NK1, #NK1R
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