VNDA

Tradipitant | ODYSSEY VLY-686-3501

COVID-19

Stage (next event)

Expected Date

Phase 3 (Safety and Efficacy Data)

TBD

Catalyst Info & Data Links

TITLE: Tradipitant for COVID-19 - Phase 3 Safety & Efficacy Data

  • ClinicalTrial.gov (NCT04326426): ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection


WHAT IS THE NEXT CATALYST EVENT?


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • TBD


PRIOR DATA

PRESS RELEASES

Mechanism of Action

MECHANSIM OF ACTION / RATIONALE

  • Tradipitant is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor; NK1R; NK-1R) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. Upon oral administration, tradipitant competitively binds to and blocks the activity of the NK1R in the central nervous system (CNS), thereby inhibiting the binding of the endogenous ligand and neuropeptide, substance P (SP; neurokinin-1; NK1). This inhibits SP/NK1-mediated signal transduction and may prevent both SP-induced emesis and pruritis. In addition, inhibition of SP/NK1R signaling also reduces neurogenic inflammation which is triggered by the release of neuropeptides, such as substance P, from nerve cells. NK1R is a G protein-coupled receptor (GPCR) that preferentially binds to SP, a neuropeptide secreted by neuronal cells and inflammatory cells. (source - National Library of Medicine (National Institute of Health))

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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