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Catalyst Info & Data Links
TITLE: VK2809 in NAFLD - TBD
ClinicalTrial.gov (NCT02927184): Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease
WHAT IS THE CATALYST EVENT?
WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?
2016: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate Safety, Tolerability and Pharmacokinetics of the Liver-Selective TR-Beta Agonist VK2809 (MB07811) in Hypercholesterolemic Subjects. (American College of Cardiology)
08-2020: Corporate Presentation (slides 8, 15, 16, 23)
2007: Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proceedings of the National Academy of Sciences, 104(39), 15490-15495.
2008: Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist. Drug metabolism and disposition, 36(11), 2393-2403.
MECHANISM OF ACTION/ RATIONALE
VK2809 belongs to a family of novel prodrugs which are cleaved in vivo to release potent thyromimetics. Selective activation of the TRß receptor in liver tissue is believed to favorably affect cholesterol and lipoprotein levels via multiple mechanisms (source).
Updated by HC
#VKTX, #VK2809, #Non-Alcoholic_Fatty_Liver_Disease, #NAFLD, #EASL
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