SUPN

Oxtellar XR® (oxcarbazepine)

Epilepsy

Stage (next event)

Expected Date

Quarterly Sales (Approved)

February 12, 2021 (Est)

Catalyst Info & Data Links

TITLE: Oxtellar XR® (oxcarbazepine) in Epilepsy - Quarterly Sales (Approved)


WHAT IS THE NEXT CATALYST EVENT?

  • Quarterly Sales (Approved)


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA

PRESS RELEASES

MECHANISM OF ACTION

  • The pharmacological activity of Oxtellar XR® is primarily exerted through the 10-monohydroxy metabolite (MHD) of oxcarbazepine [see Clinical Pharmacology (12.3)]. The precise mechanism by which oxcarbazepine and MHD exert their antiseizure effect is unknown; however, in vitro electrophysiological studies indicate that they produce blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses. These actions are thought to be important in the prevention of seizure spread in the intact brain. In addition, increased potassium conductance and modulation of high-voltage activated calcium channels may contribute to the anticonvulsant effects of the drug. No significant interactions of oxcarbazepine or MHD with brain neurotransmitter or modulator receptor sites have been demonstrated (Learn more HERE).

MARKET

  • In 2015, 1.2% of the US population had active epilepsy (95% CI* = 1.1-1.4). This is about 3.4 million people with epilepsy nationwide: 3 million adults and 470,000 children (Learn more at CDC's Epilepsy Data and Statistics)

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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