SUPN

MYOBLOC® (rimabotulinumtoxinB)

Cervical Dystonia Sialorrhea

Stage (next event)

Expected Date

Quarterly Sales (Approved)

February 12, 2021 (Est)

Catalyst Info & Data Links

TITLE: MYOBLOC® (rimabotulinumtoxinB) in Cervical Dystonia Sialorrhea - Quarterly Sales (Approved)


WHAT IS THE NEXT CATALYST EVENT?

  • Quarterly Sales (Approved)


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA

PRESS RELEASES

Mechanism of Action

MECHANISM OF ACTION

  • MYOBLOC blocks cholinergic transmission at the neuromuscular and salivary neuroglandular junction by inhibiting the release of acetylcholine from peripheral cholinergic nerved terminals. This inhibition occurs according to the following sequence: neurotoxin binding to cholinergic nerve terminals, internalization of the neurotoxin into the nerve terminal, translocation of the light-chain part of the molecule into the cytosol of the nerve terminal, and enzymatic cleavage of synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin), a presynaptic target protein essential for the release of acetylcholine. In both muscles and glands, impulse transmission is reestablished by the formation of new nerve endings (Learn more HERE).

COMPETITORS

MARKET

  •  The exact incidence or prevalence of cervical dystonia in the general population is unknown but is estimated to be about 60,000 people in the United States (Learn more at National Organization for Rare Diseases).

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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