PBYI

Neratinib

Metastatic Non-Small Cell Lung Cancer

Stage (next event)

Expected Date

Phase 2

H1 2021

Catalyst Info & Data Links

TITLE: Neratinib for Metastatic Non-Small Cell Lung Cancer

  • ClinicalTrials.gov (NCT01953926): Neratinib HER Mutation Basket Study (SUMMIT)


WHAT IS THE CATALYST EVENT?

  • Phase 2 Data


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA/EVENTS

PRESS RELEASE

Mechanism of Action

MECHANISM OF ACTION

  • Neratinib is an intracellular kinase inhibitor that irreversibly binds to epidermal growth factor receptor (EGFR), HER2, and HER4. In vitro, neratinib reduces EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in EGFR and/or HER2 expressing carcinoma cell lines. Neratinib human metabolites M3, M6, M7 and M11 inhibited the activity of EGFR, HER2, and HER4 in vitro. In vivo, oral administration of neratinib inhibited tumor growth in mouse xenograft models with tumor cell lines expressing HER2 and EGFR.

MARKET

  • ~228,820 adults (116,300 men and 112,520 women) in the United States will be diagnosed with lung cancer.

  • Learn more at Cancer.net

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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