Narsoplimab (MASP-2 inhibitor, lectin pathway)

Hematopoietic Stem Cell Transplant Associated Thrombotic Microangiopathy (HSCT-TMA)

Stage (next event)

Expected Date

BLA Acceptance

January 31, 2020 (Est)

Catalyst Info & Data Links

Mechanism of Action


  • Narsoplimab is a human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of the complement system. The lectin pathway is one of the principal pathways of complement and is activated primarily by tissue damage and microbial infection. Importantly, inhibition of MASP-2 does not appear to interfere with the classical complement pathway, a critical component of the acquired immune response to infection. This novel, proprietary drug is designed to prevent complement-mediated inflammation and endothelial damage while leaving intact the respective functions of the other pathways of innate immunity (Learn more HERE). 

Updated by HC

Prior Data (click to view full image)


Trial Design / Revenue (click to view full image)


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