Stage (next event)
January 31, 2020 (Est)
Catalyst Info & Data Links
TITLE: Narsoplimab in Hematopoietic Stem Cell Transplant Associated Thrombotic Microangiopathy - BLA Acceptance
ClinicalTrial.gov (NCT04247906): Single Patient Expanded Access Treatment Plan For The Investigational Product Narsoplimab
WHAT IS THE CATALYST EVENT?
WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?
January 31, 2021 (Est)
06-12-2020 NARSOPLIMAB PIVOTAL TRIAL DATA SHARED
Mechanism of Action
MECHANISM OF ACTION / RATIONALE
Narsoplimab is a human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of the complement system. The lectin pathway is one of the principal pathways of complement and is activated primarily by tissue damage and microbial infection. Importantly, inhibition of MASP-2 does not appear to interfere with the classical complement pathway, a critical component of the acquired immune response to infection. This novel, proprietary drug is designed to prevent complement-mediated inflammation and endothelial damage while leaving intact the respective functions of the other pathways of innate immunity (Learn more HERE).
Updated by HC
Prior Data (click to view full image)
Trial Design / Revenue (click to view full image)
See what the community is saying - click to see full post