NVAX

Matrix-M (with Serum Institute of India)

Malaria Vaccine

Phase 2b (Top-line Data)

Exp Date

H2 2020

Amp Volatility Score

Catalyst Info & Data Links

TITLE: Matrix-M Adjuvant in Malaria Vaccine - Top-line Data


WHAT IS THE CATALYST EVENT?


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA


PRESS RELEASES


MECHANISM OF ACTION/RATIONALE


Matrix-M™ is Novavax’ next-generation, patented  saponin-based adjuvant, powered by a new formulation that provides a potent adjuvant effect and is well-tolerated. Saponins are steroid or triterpenoid glycosides, which occur in many plant species.  In Matrix-M, purified saponin fractions are mixed with synthetic cholesterol and a phospholipid to form stable particles than can be readily formulated with a variety of vaccine antigens.  Saponin-based adjuvants act in part by stimulating the entry of antigen-presenting cells into the injection site and enhancing antigen presentation in the local lymph nodes. Thus, Matrix-M™ induces both a cell-mediated and an antibody mediated immune response, which we expect will be important in developing future vaccines. Matrix-M™ also increases the opportunity for an immune reaction with longer duration, which can reduce the number of vaccinations needed to gain optimal protection. (See details)



Updated by HC

Novavax, NVAX, Matrix-M, Malaria Vaccine

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