Amp Volatility Score
Catalyst Info & Data Links
TITLE: MRK and IAVI COVID-19 vaccine (rVSVΔG-SARS-CoV-2) - Preclinical Data
WHAT IS THE CATALYST EVENT?
WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?
MECHANISM OF ACTION/RATIONALE
Vesicular stomatitis virus (VSV) is a prototypic enveloped animal virus that has been used extensively to study virus entry, replication and assembly due to its broad host range and robust replication properties in a wide variety of mammalian and insect cells. Studies on VSV assembly led to the creation of a recombinant VSV in which the glycoprotein (G) gene was deleted. (Source)
The glycoprotein of VSV was replaced by the spike protein of the SARS-CoV-2 (Source)
Prior Data (click to view full image)
Trial Design / Revenue (click to view full image)
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