MESO

MPC-06-ID (Rexlemestrocel)

Chronic Low Back Pain

Stage (next event)

Expected Date

Phase 3

Q4 2020

Catalyst Info & Data Links

TITLE: MPC-06-ID (Rexlemestrocel) in Chronic Low Back Pain - Phase 3 Data

  • ClinicalTrial.gov (NCT02412735): Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Subjects With Chronic Low Back Pain (MSB-DR003)


WHAT IS THE CATALYST EVENT?

  • Phase 3 Data


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA/EVENTS

PRESS RELEASES

posters and publications

Mechanism of Action

MECHANISM OF ACTION / RATIONALE

  • MPC-06-ID is a tier 1 product candidate which consists of a unit dose of 6 million mesenchymal precursor cells (MPCs). It is injected by syringe directly into a targeted damaged disc in an outpatient procedure.

  • Extensive preclinical studies have established that MPCs have anti-inflammatory effects and secrete multiple paracrine factors that stimulate new proteoglycan and collagen synthesis by chondrocytes in vitro and by resident cells in the nucleus and annulus in vivo. MPCs have also been shown to produce anti-inflammation factors. Together these effects offer the potential to strengthen the load bearing function of the disc by increasing its water content, improving disc anatomy and stability, while also reducing inflammation and pain.

  • Learn more HERE

MARKET

  • Over four million patients in the United States alone suffer from chronic low back pain.

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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