KRYS

B-VEC (Topical Beremagene Geperpavec)

Dystrophic Epidermolysis Bullosa (DEB)

Stage (next event)

Expected Date

Phase 3 (Top-line Data & BLA)

2021

Catalyst Info & Data Links

TITLE: B-VEC (Topical Beremagene Geperpavec) in Dystrophic Epidermolysis Bullosa - Phase 3

  • ClinicalTrial.gov (NCT04491604): The Objective of This Study is to Compare the Efficacy and Safety of Beremagene Geperpavec (B-VEC) Topical Gel With That of Placebo for the Treatment of Dystrophic Epidermolysis Bullosa (DEB).

  • ClinicalTrial.gov (NCT04214002): The Natural History of Wounds in Patients With Dystrophic Epidermolysis Bullosa (DEB)


WHAT IS THE NEXT CATALYST EVENT?

  • Phase 3 (Top-line Data & BLA)


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA

PRESS RELEASES

Mechanism of Action

MECHANISM OF ACTION

  • Beremagene geperpavec ("B-VEC", previously "KB103"), a replication-defective, non-integrating HSV-1 that is based on the company's viral gene therapy platform, is Krystal's lead product candidate currently being evaluated in humans and is the subject of a planned phase III clinical trial. B-VEC has been engineered to deliver wild-type human type VII collagen genes (and thus, functional COL7 protein) directly to a DEB patient's dividing and non-dividing skin cells, providing molecular correction of the underlying genetic deficiency to stabilize the patient's otherwise extremely fragile skin (Learn more HERE). 

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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