KPTI

Selinexor

Liposarcoma | SEAL

Stage (next event)

Expected Date

NDA submission

Q1 2021

Catalyst Info & Data Links

POSTERS


PRESENTATIONS


PUBLICATIONS

Mechanism of Action

MECHANISM OF ACTION/RATIONALE

  • Nuclear export inhibitor

  • Inhibits XPO1 (see slide 5), which is believed to impact tumor cells in 3 ways

1. Increases nuclear levels and activation of tumor suppressor proteins
2. Traps oncoprotein mRNA in the nucleus leading to reduced oncoprotein levels
3. Retains activated glucocorticoid receptor in the nucleus

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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