CRC (combination with pembrolizumab) and NSCLC (combination with docetaxel) | XPORT-STP-027

Phase 1

Exp Date


Amp Volatility Score

Catalyst Info & Data Links

Potential Catalyst Events

  • TBA

Clinical Trial

  • NCT04256707: Bioequivalence and the Tolerability and Antitumor Activity of Selinexor Combination Treatment (SPRINT)

Prior Data Links

HC updated 5/22/20


  • Nuclear export inhibitor

  • Inhibits XPO1 (see slide 5), which is believed to impact tumor cells in 3 ways

1. Increases nuclear levels and activation of tumor suppressor proteins
2. Traps oncoprotein mRNA in the nucleus leading to reduced oncoprotein levels
3. Retains activated glucocorticoid receptor in the nucleus

Prior Data (click to view full image)


Trial Design / Revenue (click to view full image)


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