KPTI

Selinexor, XPOVIO (Moderate or Severe COVID-19)

COVID-19 Therapy

Phase 2 (Data)

Exp Date

Mid-Late 2020

Amp Volatility Score

Catalyst Info & Data Links

Potential Catalyst Events


Related Links


Prior Work



HC updated 5/22/20

MECHANISM OF ACTION/RATIONALE

  • Nuclear export inhibitor

  • Inhibits XPO1 (see slide 5), which is believed to impact tumor cells in 3 ways

1. Increases nuclear levels and activation of tumor suppressor proteins
2. Traps oncoprotein mRNA in the nucleus leading to reduced oncoprotein levels
3. Retains activated glucocorticoid receptor in the nucleus

Prior Data (click to view full image)

Chart

Trial Design / Revenue (click to view full image)

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Recent Posts

See What The Community Is Saying - Click To See Full Post

KPTI's Q2 XPOVIO Net Sales...

KPTI announced their Q2 2020 XPOVIO net product sales of $18.6 Million. See AmpCard for more details. #KPTI, #XPOVIO, #SELINEXOR, #Multiple_myeloma, #STORM...

Educational video - Near-term ...

Check out my recent video in our educational forum, which discusses the unfortunate reality of small and mid-cap biopharma investing: near-term dilution. Case studies are provided for CARA and TGTX, ...

KPTI's Upcoming ASCO Presentat...

We invest in KPTI because they have an enterprise value below $2 billion, and an approved oral blood cancer drug, XPOVIO (Selinexor), with a new mechanism of action and blockbuster potential. XPOVIO i...

KPTI dilution event not a surp...

After reporting positive top-line Phase 3 results today, KTPI announced a follow-on offering. I provide more details about why this is not surprising as a comment to my Amp educational video to follow...

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