IFRX

IFX-1 (vilobelimab)

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAVs)

Phase 2

Exp Date

2021

Amp Volatility Score

N/A

Catalyst Info & Data Links

MECHANISM OF ACTION

  • IFX-1 is a first-in-class monoclonal anti-human complement factor C5a antibody, which highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood. Thus, IFX-1 leaves the formation of the membrane attack complex (C5b-9) intact as an important defense mechanism, which is not the case for molecules blocking the cleavage of C5. IFX-1 has been demonstrated to control the inflammatory response driven tissue and organ damage by specifically blocking C5a as a key “amplifier” of this response in pre-clinical studies. IFX-1 is believed to be the first monoclonal anti-C5a antibody introduced into clinical development. Approximately 300 people have been treated with IFX-1 in clinical trials, and the antibody has been shown to be well tolerated. IFX-1 is currently being developed for various indications, including Hidradenitis Suppurativa, ANCA-associated vasculitis, Pyoderma Gangraenosum and COVID-19 pneumonia.

Updated by HC

#IFRX, #IFX-1, #vilobelimab, #Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAVs), #rare autoimmune diseases, #inflammation

Prior Data (click to view full image)

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