GTHX

Trilaciclib

Metastatic Colorectal Cancer

Stage (next event)

Expected Date

Phase 3 TBA

TBA

Catalyst Info & Data Links

TITLE: Trilaciclib for Metastatic Colorectal Cancer Phase 3 TBA


WHAT IS THE CATALYST EVENT?

  •  Phase 3 


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • TBA


PRIOR DATA/EVENTS

PRESS RELEASES


05-06-2020: Initiate Phase 3 clinical trial of trilaciclib in colorectal cancer in 4Q20.

MECHANISM OF ACTION / RATIONALE

  • Trilaciclib is a small molecule, competitive inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), with potential antineoplastic and chemoprotective activities. Upon intravenous administration, trilaciclib binds to and inhibits the activity of CDK4/6, thereby blocking the phosphorylation of the retinoblastoma protein (Rb) in early G1. This prevents G1/S phase transition, causes cell cycle arrest in the G1 phase, induces apoptosis, and inhibits the proliferation of CDK4/6-overexpressing tumor cells. In patients with CDK4/6-independent tumor cells, G1T28 may protect against multi-lineage chemotherapy-induced myelosuppression (CIM) by transiently and reversibly inducing G1 cell cycle arrest in hematopoietic stem and progenitor cells (HSPCs) and preventing transition to the S phase. This protects all hematopoietic lineages, including red blood cells, platelets, neutrophils and lymphocytes, from the DNA-damaging effects of certain chemotherapeutics and preserves the function of the bone marrow and the immune system. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types. HSPCs are dependent upon CDK4/6 for proliferation. (Source - National Library of Medicine National Center for Biotechnology Information)

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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