ESPR

Bempedoic Acid (Nexletol)

Elevated LDL-C (not adequately controlled with statins)

Quarterly Sales (approved)

Exp Date

August 10, 2020

Amp Volatility Score

32%

Catalyst Info & Data Links

TITLE: Bempedoic acid (Nexletol) in LDL-C (FDA-approved drug) - Quarterly Sales


WHAT IS THE CATALYST EVENT?

  • Quarterly sales 


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA/EVENTS 


PRESS RELEASE

COMPETITORS


PSK9 Inhibitors:

MARKET

  • ~ 62.6 M US adults have elevated levels of LDL-C (also known as hypercholesterolemia)

  • ~ 27.4 M US adults with elevated LDL-C levels are taking a statin

  • ~ 19.4 M patients with elevated LDL-C levels are currently unable to achieve their LDL-C targetdespite taking statin therapy

  • (Source)

MECHANISM OF ACTION/RATIONALE

  • Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is expressed primarily in the liver. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors. (Source)

Updated by HC

ESPR, Bempedoic Acid, Nexletol, LDL-C, Elevated LDL-C, high cholestrol, Quarterly Sales

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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