EIGR

Zokinvy™ (lonafarnib)

Progeria and Progeroid Laminopathies

Stage (next event)

Expected Date

Quarterly Sales (Approved)

March 12, 2021

Catalyst Info & Data Links

Mechanism of Action

MECHANISM OF ACTION

  • Lonafarnib is a well‐characterized, late‐stage, orally active inhibitor of farnesyltransferase, an enzyme involved in modification of proteins through a process called prenylation.  Progerin is a farnesylated, aberrant protein that researchers believe cannot be cleaved, resulting in tight association with the nuclear envelope, which leads to changes in nuclear envelope morphology and subsequent cellular damage. 

Updated by HC

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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