DVAX

Vaccine Candidate (with Coalition for Epidemic Preparedness Innovations (CEPI) and Queensland)

COVID-19 Vaccine

Stage (next event)

Expected Date

Pre-Clinical

TBD

Catalyst Info & Data Links

TITLE:  COVID-19 Vaccine Candidate (with Coalition for Epidemic Preparedness Innovations (CEPI) and Queensland)


WHAT IS THE NEXT CATALYST EVENT?

  • Phase 1 trial


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • TBD


PRIOR DATA
PRESS RELEASES

Mechanism of Action

MECHANISM OF ACTION 

  • CpG 1018 has been studied clinically and developed as a vaccine adjuvant for Dynavax’s hepatitis B vaccine, HEPLISAV-B. The pre-clinical and clinical studies demonstrate that the addition of CpG 1018 increases antibody concentrations, stimulates helper (CD4+) and cytotoxic (CD8+) T cell populations and generates robust T and B cell memory responses. Additionally, CpG 1018 strongly favors development of the Th1 subset of helper T cells, the type of helper T cell that is essential for protection from infections with viruses and intracellular bacteria. CpG 1018 targets a single, well defined receptor (TLR9) expressed on only a few key cell types and the mechanisms of action as an adjuvant are quite well understood. CpG 1018 provides a well‑developed technology and a significant safety database, potentially accelerating the development of novel vaccines

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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