COVID-19 Vaccine (with Medicago)

COVID-19 Vaccine

Phase 1 (Preliminary safety and immunogenicity results)

Exp Date


Amp Volatility Score

Catalyst Info & Data Links



  • CpG 1018 has been studied clinically and developed as a vaccine adjuvant for Dynavax’s hepatitis B vaccine, HEPLISAV-B. The pre-clinical and clinical studies demonstrate that the addition of CpG 1018 increases antibody concentrations, stimulates helper (CD4+) and cytotoxic (CD8+) T cell populations and generates robust T and B cell memory responses.

  • Adjuvants are a pharmacological or immunological substance that is combined with a specific protein (antigen) in a vaccine to help stimulate an immune response against the antigen. Some adjuvants work by stimulating specific immune pathways, such as toll like receptor 9 (TLR9), that promote stronger immune responses than with antigens alone.

  • Combining COVID-19 surface antigens with CpG 1018 for the vaccine to elicit a higher antibody titer. 

  • (Source)

Updated by MV

#COVID-19, #Dynavax, #CpG1018, #Coronavirus, #DVAX

Prior Data (click to view full image)


Trial Design / Revenue (click to view full image)


Recent Posts

See What The Community Is Saying - Click To See Full Post

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Heplisav-B, which was approved by the FDA in 2018, saw a large drop in sales in Q2 2020. The sales for Q2 2020 were $2.4M which is very low compared to Q1 2020 which was about $10.5M. Also, it is impo...

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DVAX is expecting to present their preliminary safety and immunogenicity results from Phase 1 COVID-19 studies in September and October 2020. See our AmpCard to learn more. #DVAX, #Dynavax, #COVID...

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