DVAX

COVID-19 Vaccine (with Medicago)

COVID-19 Vaccine

Stage (next event)

Expected Date

Phase 1 (Preliminary safety and immunogenicity results)

Q4 2020 (Est)

Catalyst Info & Data Links

Title: COVID-19 Vaccine from Dynavax and Medicago Phase 1 (Preliminary safety and immunogenicity results)


WHAT IS THE NEXT CATALYST EVENT?

  • Phase 1 (Preliminary safety and immunogenicity results)

WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • Q4 2020 (Est)


PRIOR DATA

PRESS RELEASES


MECHANISM OF ACTION

  • CpG 1018 has been studied clinically and developed as a vaccine adjuvant for Dynavax’s hepatitis B vaccine, HEPLISAV-B. The pre-clinical and clinical studies demonstrate that the addition of CpG 1018 increases antibody concentrations, stimulates helper (CD4+) and cytotoxic (CD8+) T cell populations and generates robust T and B cell memory responses.

  • Adjuvants are a pharmacological or immunological substance that is combined with a specific protein (antigen) in a vaccine to help stimulate an immune response against the antigen. Some adjuvants work by stimulating specific immune pathways, such as toll like receptor 9 (TLR9), that promote stronger immune responses than with antigens alone.

  • Combining COVID-19 surface antigens with CpG 1018 for the vaccine to elicit a higher antibody titer. 

  • (Source)

COMPETITORS

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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