DVAX

COVID-19 S-Trimer (with Clover Biopharmaceuticals)

COVID-19 Vaccine

Stage (next event)

Expected Date

Phase 1 (Preliminary safety and immunogenicity results)

Q4 2020 (Est)

Catalyst Info & Data Links

MECHANISM OF ACTION

  • SCB-2019 is a recombinant subunit vaccine candidate for COVID-19.  Utilizing our patented Trimer-Tag© technology, Clover has produced a S-Trimer subunit vaccine candidate that resembles the native trimeric viral spike via mammalian cell-culture production system.

  • Adjuvant CpG 1018 has been studied clinically and developed as a vaccine adjuvant for Dynavax’s hepatitis B vaccine, HEPLISAV-B. The pre-clinical and clinical studies demonstrate that the addition of CpG 1018 increases antibody concentrations, stimulates helper (CD4+) and cytotoxic (CD8+) T cell populations and generates robust T and B cell memory responses. Additionally, CpG 1018 strongly favors development of the Th1 subset of helper T cells, the type of helper T cell that is essential for protection from infections with viruses and intracellular bacteria. CpG 1018 targets a single, well defined receptor (TLR9) expressed on only a few key cell types and the mechanisms of action as an adjuvant are quite well understood. CpG 1018 provides a well‑developed technology and a significant safety database, potentially accelerating the development of novel vaccines.

COMPETITORS

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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