Heart Failure with Reduced Ejection Fraction (HFrEF)

Stage (next event)

Expected Date

Phase 3 Data


Catalyst Info & Data Links

Mechanism of Action


  • Omecamtiv mecarbil stimulates cardiac myosin, a protein responsible for converting chemical energy into the mechanical force that results in contraction of the heart. It is designed to improve cardiac muscle performance, potentially helping patients preserve cardiac function and quality of life, avoid hospitalizations, and decrease the risk of death due to heart failure. Preclinical research has shown that cardiac myosin activators increase cardiac contractility without affecting intracellular myocyte calcium concentrations or myocardial oxygen consumption.

Updated by HC

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Trial Design / Revenue (click to view full image)


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