CYDY

Leronlimab (PRO 140)

COVID-19

Phase 3 (Results)

Exp Date

Mid-October 2020

Amp Volatility Score

Catalyst Info & Data Links

TITLE: Leronlimab (PRO 140) in COVID - Phase 3 (Results)

  • ClinicalTrial.gov (NCT04347239): Study to Evaluate the Efficacy and Safety of Leronlimab for Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)

  • ClinicalTrial.gov (NCT04343651): Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19


WHAT IS THE CATALYST EVENT?

  • Phase 3 Results


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?


PRIOR DATA

PRESS RELEASES

MECHANISM OF ACTION / RATIONALE

  • A humanized immunoglobulin (Ig) G4 monoclonal antibody against CC chemokine receptor 5 (CCR5; CD195), with potential activity as a human immunodeficiency virus (HIV) entry blocker and potential protective activity against graft-versus-host disease (GvHD). Upon administration, leronlimab targets and binds to CCR5 expressed on T cells. This blocks HIV cell entry, which prevents HIV infection and/or reduces HIV viral load. In addition, blocking CCR5 by leronlimab decreases CCR5-mediated signaling and the CCR5-induced migration of donor cells into tissues after an allogeneic hematopoietic cell transplantation (HCT). Blocking CCR5 may therefore prevent or reduce GvHD. CCR5, a co-receptor needed for HIV cell entry, plays a key role in immunomodulation. Expressed on monocytes, activated T cells and dendritic cells (DCs), CCR5 can regulate chemotaxis. Lymphocyte trafficking via chemokine receptors, such as CCR5, and recruitment to target organs, plays a critical role in alloreactive responses (Learn more - National Cancer Institute)

Updated by HC

#CYDY, #Leronlimab, #PRO140, #CCR5, #COVID, #Antibody

Prior Data (click to view full image)

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