CARA

Oral Korsuva

Pruritus CLD

Stage (next event)

Expected Date

Phase 2 Topline Data

H1 2021

Catalyst Info & Data Links

TITLE: Oral Korsuva Pruritus CLD - Topline Data

  • ClinicalTrial.gov (NCT03995212): Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus

  • About CLD


WHAT IS THE CATALYST EVENT?


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • H1 2021


PRIOR DATA/EVENTS


PRESS RELEASES

PRESENTATIONS

Mechanism of Action

MECHANISM OF ACTION / RATIONALE

  • Difelikefalin (CR845) is a peripherally restricted, selective kappa opioid receptor agonist that exerts antipruritic effects by means of activation of kappa opioid receptors on peripheral neurons and immune cells. The hydrophilic small-peptide structure restricts passive diffusion across membranes, thereby limiting access to kappa opioid receptors in the central nervous system (Fishbane et al., 2020).


COMPETITORS

MARKET

  • ~7 million patients were diagnosed with CLD in 2013 in the US

  • ~2.5 million patients received a prescription for an anti-pruritic

  • source

Updated by MV

Prior Data (click to view full image)

Chart

Trial Design / Revenue (click to view full image)

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