CARA

Oral Korsuva

Atopic Dermatitis

Stage (next event)

Expected Date

Phase 2 (Top-line results)

H1 2021

Catalyst Info & Data Links

TITLE: Oral Korsuva for Atopic Dermatitis - Topline Data

  • ClinicalTrial.gov (NCT04018027): Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis (KARE)


WHAT IS THE CATALYST EVENT?


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • H1 2021


PRIOR DATA


PRESS RELEASE

POSTERS


PRESENTATIONS


PUBLICATIONS

MECHANISM OF ACTION 


Opioid analgesics can act through three different types of opioid receptors, called mu, delta, and kappa. Morphine, the most widely used opioid analgesic, acts primarily via activation of the mu opioid receptor located in the central nervous system (CNS). This CNS action induces pain relief but is also associated with a wide array of CNS-mediated side effects including nausea/vomiting, sedation, respiratory depression, and abuse liability. As a way to avoid these undesirable CNS and mu opioid mediated side effects, there has been an effort to develop opioids which activate peripheral kappa opioid receptors present on sensory nerves, immune cells and the dorsal root ganglion (DRG). Such compounds, Kappa Opioid Receptor Agonists (KORAs), are thought to have the potential to provide pain relief (peripheral opioid analgesia) without producing significant CNS and mu-opioid mediated side effects.

COMPETITORS

MARKET

  • ~20 Million

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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