BLPH

INOpulse

PH-ILD

Stage (next event)

Expected Date

Phase 2

TBD

Catalyst Info & Data Links

Mechanism of Action

MECHANISM OF ACTION

  • Nitric oxide is normally produced in the blood vessel endothelium linings, working on the smooth muscle of the blood vessels to dilate or open the arteries. When nitric oxide enters the smooth muscle cells, it directly activates a chemical called soluble guanylate cyclase (sGC) in these cells. sGC produces another substance called cyclic guanosine monophosphate (GMP). Cyclic GMP then causes the smooth muscle cells to relax, which in turn causes the blood vessels (arteries) to widen or dilate also known as vasodilation.

  • Learn more here

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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