APTO

CG-806 (BTK Inhibitor)

B-cell malignancies (NHL & CLL)

Stage (next event)

Expected Date

Phase 1 (Data Presentation at ASH)

December 5, 2020

Catalyst Info & Data Links

TITLE: CG-806 in B-cell malignancies

  • ClinicalTrials.gov (NCT03893682): A Study of CG-806 in Patients With Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas


WHAT IS THE CATALYST EVENT?

  • ASH 2020 presentation


WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR?

  • December 5, 2020


PRIOR DATA/EVENTS


COMPARATIVE TABLES


PRESS RELEASE

Mechanism of Action

MECHANISM OF ACTION / RATIONALE

  • CG-806 targets the ATP-binding pocket of Bruton’s tyrosine kinase (BTK), a driver of B-cell malignancy, through a reversible, non-covalent mechanism, thereby allowing CG-806 to retain low nM potency against both wildtype as well as mutant (e.g. Cys481Ser) forms of the enzyme and to exert superior potency relative to ibrutinib against primary samples from the bone marrow of patients with B-cell cancers. Of note, CG-806 inhibits phosphorylation of BTK, as well as BLK, ITK, LCK, LYN and SRC of the BCR pathway, and this allows CG-806 to hit the pathway at multiple critical nodes and to kill the B-cell cancer cells. Importantly, CG-806 does not inhibit TEC, EGFR or ErbB2 kinases which are implicated in the toxicities of other BTK inhibitors, including bleeding disorders, gut and skin toxicity, and atrial fibrillation, respectively. (Source)

COMPETITORS


Bruton’s tyrosine kinase (BTK) inhibitor:

  • ARQL 531 - Merck (acquired Arqule)

  • LOXO-305 - Eli Lilly and Company

  • SNSS-062 - Sunesis

  • GDC-0853 - Genentech

MARKET

  • ~77,240 people will be diagnosed with NHL in the US (source)

  • ~21,040 people will be diagnosed with CLL in the US (source)

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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Recent Posts

See what the community is saying - click to see full post

Merck acuires Arqule: Non-covalent Btk kinase inhibitors take center stage

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