APTO

APTO-253

RR Acute Myelogenous Leukemia/ HR Myelodysplasia

Phase 1 (ASH Data Presentation)

Exp Date

Dec 5-8, 2020

Amp Volatility Score

Catalyst Info & Data Links

COMPETITORS

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  • ~13K MDS incidence per year in the U.S.

  • ~30% of MDS cases progress to AML

  • ~35.7K prevalence for AML 

  • ~18.8K Patients with new AML diagnoses 

  • (Source)

MECHANSIM OF ACTION/RATIONALE

  • APTO-253 as a Small Molecular MYC Inhibitor: APTO-253 does not target directly the MYC protein, but rather binds directly and selectively to a regulatory motif in the promoter of the MYC oncogene and dramatically down-regulates expression of the MYC protein in tumor cells, leading to apoptotic cell death. Thus, APTO-253 may serve as a safe and effective MYC inhibitor for MYC-driven or MYC-dependent tumors that combines well with other anti-tumor agents.

Updated by HC

APTO, APTO-253, acute_myeloid_leukemia, myelodysplastic_syndrome, ASH, ASH2020

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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APTO EHA 2020 ...

APTO is presenting data at EHA 2020 for their BTK and FLT-3 inhibitor CG-806 at EHA. Get our take on the likely movement and our investment strategy going forward. CLICK HERE (Free sign-up required fo...

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