AGEN

Allogenic iNTKs

Cancer

Stage (next event)

Expected Date

Phase 1

Q4 2020

Catalyst Info & Data Links

TITLE: Allogenic iNTKs for Cancer treatment Phase 1 Commencement


WHAT IS THE NEXT CATALYST EVENT?

  • Phase 1 trial commencement

WHEN WILL THE EVENT (OR DID THE EVENT) OCCUR? 

  • Q4 2020

PRIOR DATA

PRESS RELEASE

Mechanism of Action

MECHANISM OF ACTION

  • Invariant natural killer T cells (iNKT cells) are a unique cell type that combines features of two critical arms of the immune system, T cells (adaptive immunity) and NK cells (innate immunity), making them invaluable in combating diseases like COVID-19 and cancer. Data from preclinical models that bear similarities to SARS-COV-2 suggest that iNKT cell therapy has the potential to eliminate the COVID-19 virus, dampen harmful inflammation, and promote protection from reinfection.

  • As for cancer, data from preclinical models show that AgenTus iNKTs can penetrate tissues, giving them a critical advantage in targeting solid tumors not currently served by approved cell therapies. These data also showed that the combination of checkpoint antibodies and iNKT cell triggering therapy shows curative potential in cancer models that are refractory to available therapies.

Updated by MV

Prior Data (click to view full image)

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Trial Design / Revenue (click to view full image)

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