Karuna Therapeutics

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Company Profile

We are an innovative clinical-stage biopharmaceutical company primarily focused on developing novel therapies to address disabling neuropsychiatric conditions characterized by significant unmet medical need.

Our pipeline is built on the broad therapeutic potential of our lead product candidate, KarXT, an oral modulator of muscarinic receptors that are located both in the central nervous system, or CNS, and various peripheral tissues. KarXT is our proprietary product candidate that combines xanomeline, a novel muscarinic agonist, with trospium, an approved muscarinic antagonist, to preferentially stimulate muscarinic receptors in the CNS.

We have assembled a team with extensive expertise in the research, development and commercialization of numerous CNS agents, as well as deep familiarity with the biology of neuropsychiatric disorders, such as schizophrenia and AD, including the role of muscarinic receptors in their potential treatment. We will leverage this expertise to develop a pipeline of product candidates targeting a broad range of psychiatric and neurological conditions.

Drug Pipeline

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Drug | Disease (links)

Stage (next event)

Catalyst Date



Phase 3 (Enrollment)

Q4 2020

Recent Posts

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Is KRTX Ph2 Schizo data as good as it initially appears?

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