Summary of findings:
Interim analysis of the ODYSSEY study showed that a 14 day tradipitant treatment accelerated clinical improvement by day 7 (HR=2.55, p=0.0375)
Tradipitant numerically improved median time to clinical improvement by day 28 (HR=1.55, p=0.2254)
However, at day 28, the tradipitant and placebo arms show similar overall rates of improvement and mortality
In our view you can look at this data from a bullish or bearish viewpoint. It's a small study and hard to reach too many conclusions other than tradipitant is not an amazingly effective Covid-19 cure, but it might have a benefit to Covid patients, helping some of them recover sooner. It will be interesting to see data from more patients, and data from HRTX's Cinvanti, which has a similar mechanism of action.
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